Selenium in intensive care

Selenium is essential

Selenium is important for the body. The essential trace element protects the organism from free radicals and is important for the thyroid gland. It improves the immune defense system and increases fecundity. Selenium is involved in the activation of numerous enzymes.

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selenase® reduces the occurrence of ventilator-associated pneumonia with sepsis

Keeping up on the latest research, biosyn has summarized a new prospective, randomized controlled trial on high-dose selenase®: The key facts from this 12-page publication highlight the positive effect of high-dose selenase® supplementation on ICU and hospital stay as well as morbidity and mortality in patients with ventilator-associated pneumonia.

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Dosing of selenase® for sepsis, heart surgery, stroke, burns and after reanimation

Correct dosing is key to achieving desired outcomes and preventing morbidity and mortality, but also varies across disease stages. Whether continuous infusion, maintenance therapy or perioperative administration, this new 12-page brochure provides evidence-based guidelines on selenium dosing in 5 major indications.

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Compatibility of Selenase

Successful treatment is highly dependent on the proper drug regimen. This is not always easy with multimorbid patients in intensive care and surgical settings. When administering drugs in infusion solutions or combinations, miscibility is one of many important factors. The table and references in this 2-page guide are extremely helpful when selenase® needs to be combined – risk-free – in 5 critical care indications.

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Use of selenium in intensive care as adjunctive therapy for sepsis, ischaemia/reperfusion and reanimation

A rich compendium of facts and figures on selenium for sepsis, ischaemia/reperfusion, cardiac surgery, stroke, burns and reanimation: biosyn’s 156-page new selenium compendium is titled “Use of selenium in intensive care as adjunctive therapy for sepsis, ischaemia/reperfusion and reanimation”.

This comprehensive collection is rich with findings from basic and clinical research from over 125 cited references. The data from randomized controlled trials like SIC, SÉRÉNITÉ, SIGNET , REDOXS and meta-analyses are abstracted in manageable form. Many of them were also carried out specifically on selenase. Divided into sections, key data relevant to each indication are illustrated in 63 understandable graphs and tables, including charts with diagnostic, dosing and miscibility criteria in these indications. At the back, the 7 internationally most important guidelines are summarized with links for readers’ convenience. 

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Sub-folders:

Selenium and burns

First in a new 5-part series: the 16-page biosyn folder “Selenium and burns” compiles studies on selenium supplementation in patients with major burns: Selenium supplementation normalizes burn-related selenium deficiency, promotes wound healing and prevents ICU- and hospital-associated sequelae.

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Selenium for cardiac surgery

Second in a new 5-part series: biosyn’s new 40-page folder “Selenium for cardiac surgery” compiles data from 46 publications on the benefits and cardio-protective effects of perioperative selenium supplementation in cardiac surgery. Biochemical and pharmacological evidence is provided that explains the functional role of selenium in the cardiovascular system.

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Selenium after resuscitation

Third in a new 5-part series: biosyn’s 16-page folder “Selenium after resuscitation” illustrates the benefits of selenium in patients suffering cardiopulmonary arrest. Selenium levels prove to be predictors of regaining consciousness and ICU mortality. Early selenase® can protect against neurological and reperfusion damage in this sepsis-like syndrome.

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Selenium for sepsis

Fourth in a new 5-part series: biosyn’s new 76-page folder “Selenium for sepsis” describes the benefits of selenase® in sepsis and SIRS. As in the sepsis-like post-cardiac arrest syndrome, early selenium plays an important role in predicting survival, reducing mortality and improving clinical outcome.

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Selenium and stroke

Fifth and last in biosyn’s 5-part series: the new 40-page folder “Selenium and stroke” highlights the biochemical role sodium selenite plays in acute and anamnestic stroke. Selenium protects neurons against hypoxic/ischaemic damage by reducing oxidative stress and restoring mitochondrial function in the brain. Studies indicate that a selenium-poor diet may be an additional risk factor for brain attacks.

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Does the SISPCT trial provide new insights regarding the use of sodium selenite for sepsis?

The long-expected SISPCT trial for using sodium selenite to treat severe sepsis and septic shock was recently published. The bifactorial trial investigated both the treatment with sodium selenite as well as the administration of antibiotics on the basis of the procalcitonin values. The hospital stay of the sepsis patients treated with sodium selenite was significantly shortened by 3 days (- 10%; p = 0.02). Please find the most frequently asked questions about the SISPCT trial in our new PDF.

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